Expanded question: What are the benefits of a fermented tonic with organic garlic, organic ginger, organic cayenne, organic apple cider vinegar, and horseradish?

Answered on October 7, 2024
The benefits of a fermented tonic containing organic garlic, organic ginger, organic cayenne, organic apple cider vinegar, and horseradish can be attributed to the bioactive compounds present in these ingredients, which have been studied for their various health-promoting properties.
Garlic: Garlic contains bioactive compounds such as (poly)phenols and organosulfur compounds (OSCs), which have been associated with antioxidant, anti-inflammatory, and antimicrobial properties. These compounds may contribute to systemic health benefits, including cardiovascular health and immune support.[1]
Ginger: Ginger is rich in bioactive compounds that exhibit antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic properties. These properties can help in reducing oxidative stress, managing inflammation, and potentially lowering the risk of infections and certain cancers.[2]
Cayenne: Cayenne pepper contains capsaicin, which has been shown to have anti-inflammatory and analgesic effects. Capsaicin can also enhance metabolism and promote cardiovascular health by improving blood circulation and reducing blood pressure.
Apple Cider Vinegar: Apple cider vinegar is known for its acetic acid content, which has been linked to antimicrobial, antidiabetic, antioxidative, antiobesity, and antihypertensive effects. Regular consumption of vinegar can help in blood glucose control, lipid metabolism regulation, and weight management.[3-4]
Horseradish: Horseradish contains isothiocyanates (ITCs), which are formed during the fermentation of glucosinolates by myrosinase. ITCs have demonstrated significant antibacterial activity, particularly against respiratory and urinary tract infections.[5]
In summary, the combination of these ingredients in a fermented tonic can provide a synergistic effect, enhancing antimicrobial, anti-inflammatory, antioxidant, and metabolic health benefits.

References

1.
Colonic Fermentation of (Poly)phenols and Organosulfur Compounds of Fresh and Black Garlic.

Moreno-Ortega A, Di Pede G, Pereira-Caro G, et al.

Journal of Agricultural and Food Chemistry. 2022;70(12):3666-3677. doi:10.1021/acs.jafc.1c08081.

The beneficial properties associated with garlic consumption have been related to the presence of bioactive compounds including (poly)phenols and organosulfur compounds (OSCs). This study aims to assess the effect of colonic fermentation on fresh and black garlic by determining the transformation of these compounds through ultrahigh-performance liquid chromatography coupled to mass spectrometry with a linear ion trap (uHPLC-LIT-MS). Colonic fermentation had a similar influence on the phenolic content of fresh and black garlic, with total respective decreases of 43.8% and 41.7%. Meanwhile, fermentation resulted in a significant decrease (33%) in OSCs in black garlic. Compounds such as 4-hydroxybenzoic acid, -allylcysteine (SAC), and methionine sulfoxide were the phenolic compounds and OSCs with the highest concentration in fresh and black garlic after the fermentation. These compounds, potentially present at the colonic level, might be responsible for the systemic health benefits associated with the consumption of black and fresh garlic.

2.
Ginger Bioactives: A Comprehensive Review of Health Benefits and Potential Food Applications.

Shaukat MN, Nazir A, Fallico B.

Antioxidants (Basel, Switzerland). 2023;12(11):2015. doi:10.3390/antiox12112015.

Leading Journal
New Research

Ginger is an herbaceous and flowering plant renowned for its rhizome, which is widely employed as both a spice and an herb. Since ancient times, ginger has been consumed in folk medicine and traditional cuisines for its favorable health effects. Different in vitro and in vivo studies have disclosed the advantageous physiological aspects of ginger, primarily due to its antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic properties. These health-promoting features are linked to the variety of bioactive compounds that are present in ginger. Following the advancement in consumer awareness and the industrial demand for organic antioxidants and functional ingredients, the application of ginger and its derivatives has been broadly investigated in a wide range of food products. The prominent features transmitted by ginger into different food areas are antioxidant and nutraceutical values (bakery); flavor, acceptability, and techno-functional characteristics (dairy); hedonic and antimicrobial properties (beverages); oxidative stability, tenderization, and sensorial attributes (meat); and shelf life and sensorial properties (film, coating, and packaging). This review is focused on providing a comprehensive overview of the tendencies in the application of ginger and its derivatives in the food industry and concurrently briefly discusses the beneficial aspects and processing of ginger.

3.
Vinegar Functions on Health: Constituents, Sources, and Formation Mechanisms.

Chen H, Chen T, Giudici P, Chen F.

Comprehensive Reviews in Food Science and Food Safety. 2016;15(6):1124-1138. doi:10.1111/1541-4337.12228.

Leading Journal

Vinegars are one of only a few acidic condiments throughout the world. Vinegars can mainly be considered grain vinegars and fruit vinegars, according to the raw materials used. Both grain vinegars and fruit vinegars, which are fermented by traditional methods, possess a variety of physiological functions, such as antibacteria, anti-infection, antioxidation, blood glucose control, lipid metabolism regulation, weight loss, and anticancer activities. The antibacteria and anti-infection abilities of vinegars are mainly due to the presence of organic acids, polyphenols, and melanoidins. The polyphenols and melanoidins also provide the antioxidant abilities of vinegars, which are produced from the raw materials and fermentation processes, respectively. The blood glucose control, lipid metabolism regulation, and weight loss capabilities from vinegars are mainly due to acetic acid. Besides caffeoylsophorose (inhibits disaccharidase) and ligustrazine (improves blood circulation), other functional ingredients present in vinegars provide certain health benefits as well. Regarding anticancer activities, several grain vinegars strongly inhibit the growth of some cancer cells in vivo or in vitro, but related functional ingredients remain largely unknown, except tryptophol in Japanese black soybean vinegar. Considering the discovering of various functional ingredients and clarifying their mechanisms, some vinegars could be functional foods or even medicines, depending on a number of proofs that demonstrate these constituents can cure chronic diseases such as diabetes or cardiovascular problems.

4.
Varieties, Production, Composition and Health Benefits of Vinegars: A Review.

Ho CW, Lazim AM, Fazry S, Zaki UKHH, Lim SJ.

Food Chemistry. 2017;221:1621-1630. doi:10.1016/j.foodchem.2016.10.128.

Leading Journal

Vinegars are liquid products produced from the alcoholic and subsequent acetous fermentation of carbohydrate sources. They have been used as remedies in many cultures and have been reported to provide beneficial health effects when consumed regularly. Such benefits are due to various types of polyphenols, micronutrients and other bioactive compounds found in vinegars that contribute to their pharmacological effects, among them, antimicrobial, antidiabetic, antioxidative, antiobesity and antihypertensive effects. There are many types of vinegars worldwide, including black vinegar, rice vinegar, balsamic vinegar and white wine vinegar. All these vinegars are produced using different raw materials, yeast strains and fermentation procedures, thus giving them their own unique tastes and flavours. The main volatile compound in vinegar is acetic acid, which gives vinegar its strong, sour aroma and flavour. Other volatile compounds present in vinegars are mainly alcohols, acids, esters, aldehydes and ketones. The diversity of vinegars allows extensive applications in food.

5.
Phytochemical and Functional Analysis of Horseradish (Armoracia Rusticana) Fermented and Non-Fermented Root Extracts.

Negro EJ, Sendker J, Stark T, Lipowicz B, Hensel A.

Fitoterapia. 2022;162:105282. doi:10.1016/j.fitote.2022.105282.

Background: The roots of horseradish (Armoracia rusticana) are used for infections of respiratory airway and for urinary tract infections due to isothiocyanates (ITC), enzymatically formed during fermentation of glucosinolates by myrosinase.

Hypothesis/purpose: The present study aims to present a comprehensive overview on the phytochemical composition of A. rusticana roots, especially concerning isothiocyanates and respective glucosinolates. The complex flavonoid spectrum of the herbal material is reviewed. Published data on in vitro activity of horseradish extracts and isolated compounds are summarized. These data indicate well-established use of horseradish as an antibacterial remedy against bacterial infections of the airway and urinary tract.

Study Design: To answer the question if other compounds from A. rusticana beside ITC contribute to the antibacterial activity, non-targeted LC-MS studies were performed with fermented and non-fermented horseradish extracts, and detailed phytochemical profiles were established.

Results: Comparative investigations on the antibacterial activity indicated that only ITC-containing extracts and fractions exert antibacterial activity. The huge variety of non-ITC compounds do not significantly contribute to the antibacterial activity, but can be used for analytical characterisation and quality control of the herbal material. Detailed phytochemical analysis additionally revealed a variety of compounds, not described until now for horseradish roots: the flavonol glycosides kaempferol-3-O-β-d-xylopyranosyl-(1''' → 2'')-β-d-galactopyranoside, kaempferol-3-O-α-l-rhamnopyranosyl-(1''' → 6'')-β-d-glucopyranoside, kaempferol-3-O-β-d-glucopyranoside, Kaempferol-3-O-β-d-xylopyranosyl-7-O-β-d-glucopyranoside, Kaempferol-3-O-β-d-xylopyranosyl-(1'''' → 2''')-β-d-galactopyranoside-7-O-β-d-glucopyranoside, the oxo-indole derivative spirobrassinin, the phenylthiazole 2-methylsulfanyl-4-phenyl-4,5-dihydro-1,3-thiazole, a series of lysophophatidylethanolamine and 13 different N-phenylpropenoyl-L-amino acids.

Conclusion: The antibacterial effects of horseradish are only due to the presence of glucosinolates resp. the corresponding ITC, and the detailed overall composition of horseradish extracts has been reported.